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  • Researchers discover novel mode of neurotransmitter-based communication.
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This computer model illustrates GABA binding to the newly discovered site on a neuronal potassium channel. Journal information: Nature Communications.

Systemic neurotransmitter responses to clinically approved and experimental neuropsychiatric drugs

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Basics of Brain Function and Neurotransmitters

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Nanomaterial-based electrochemical sensing of neurological drugs and neurotransmitters

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Lecture 6 - Neurotransmission and Neurotransmitters -Drugs and Human Behavior 2019

E-mail newsletter. Though traditionally drug developers have targeted proteins in an active state, the researchers found that iGluRs in a resting state are highly mobile and dynamic, which profoundly affects how they respond to drugs. A major drug target for decades, despite their importance, few drugs targeting iGluRs have reached the clinic for the treatment of neurological disease. The discovery came about serendipitously, spawning from an unplanned discussion between Bowie and Dr. Jette Sandholm Kastrup in Copenhagen in Bowie and I discussed the idea that AMPA receptors -- the most common type of receptors found in the nervous system -- might be modulated by anions," says Dr.

Kastrup, Professor at the University of Copenhagen and one of the study's senior authors. Our work, using X-ray crystallography, allowed us to locate the anion binding site in the atomic structure of the AMPA receptor.

Cerebral blood flow predicts differential neurotransmitter activity | Scientific Reports

Kastrup thought that this new crystallized AMPA-type ionotropic glutamate receptor her lab had developed could help shed light on an observation Dr. Bowie had made in Upon his return to McGill, Dr. Bowie's lab used the crystallized structure to help identify that a single amino acid was responsible for determining whether different genetic isoforms of the same AMPA receptor could be either fully regulated or not regulated at all. The next important breakthrough then came, again by chance, when Dr. Bowie visited Cambridge in and met with Dr.

Mike Edwardson, who had been working with Dr. Bowie shared some of the unpublished data and Dr. Edwardson agreed to run a few experiments.

Basics of Brain Function and Neurotransmitters

Edwardson, the Sheild Professor of Pharmacology at the University of Cambridge and senior author on the paper. The impact of the findings have broad appeal to many other signaling proteins inside and outside of the brain. Consequently, the study uncovers an important aspect of biology that may need to be considered when developing drugs in the future. Our recent study shows that assumption needs to be revised, which opens up an entirely new area of study that could have impact on other areas of investigation such as in cancer, heart disease in addition to our findings on an important brain neurotransmitter receptor.

Materials provided by McGill University. Note: Content may be edited for style and length. Science News. A series of fortunate events The discovery came about serendipitously, spawning from an unplanned discussion between Bowie and Dr.

Journal Reference : G. Brent Dawe, Md.